Endocrine Abstracts

Background: Papillary thyroid carcinomas are the most common thyroid malignancies. They are more prevalent in women and have a bimodal age distribution. Thyroglossal duct cyst carcinomas are extremely rare (occurring in only 1% of all thyroglossal duct cysts). The large majority of these carcinomas are of thyroid origin.Case presentation: A 25-year-old woman with no significant medical history was referred to the Endocrinologist with 1-month complaints o...

Introduction: Acromegaly is a rare disease which results from a GH producing adenoma. Around 70–80% are macroadenomas. The therapeutic options currently available are surgery, radiotherapy (RT) and medical treatment (MT). According to literature microadenomas have a higher remission rate, around 80%.Methods: A retrospective chart review of the patients with acromegaly treated in our centre from 1976 to 2011 was performed. In terms of disease control...

Transthyretin (TTR) is well documented as a carrier for thyroid hormones. It also binds retinol binding protein preventing its filtration trough the kidneys and therefore is involved in delivering retinol to target cells. Moreover, TTR sequesters amyloid-beta impairing its deposition in nervous tissues and possibly contributing to its removal. Despite its importance in mammalian physiology, there are few studies regarding the regulation of TTR synthesis. In silico analy...